Contribution of Left Atrial Epicardial Fat Quantification by Computed Tomography and Left Atrial Strain by MRI in Atrial-Fibrilation Ablation: The CTStrain-AF Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Atrial fibrillation ablation (AF) is a standard interventional treatment for patients with symptomatic AF refractory to medical treatment. The known predictive factors for the success of the procedure remain insufficient to predict the probabilities of success and to appropriately select the patients who could benefit the most from this procedure. Left atrium imaging by MRI or CT may be able to identify AF substrate. However data are lacking about the practical impact of these techniques in routine practice to predict AF ablation outcome. The CT-AF study is a prospective, interventional, multicenter cohort study. The main objective of this study is to evaluate the prognostic value of a new automated measurement technique for intra-myocardial atrial fat measurement in cardiac CT and the measurement of global left atrial strain in MRI in patients who are candidates for first AF ablation. The main outcome will be the relationship between the relative volume of left atrial fat measured with CT and total left atrial strain in MRI and recurrence of AF at 1 year after the ablation procedure (blanking period of 3 months post ablation excluded).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient in whom radiofrequency AF ablation is scheduled within the next 6 months.

• age ≥18 years

• Patient affiliated to a social security scheme

• Patient informed and given written consent for participation in the study.

Locations
Other Locations
France
Centre Hospitalier Universitaire Pitie-Salpetriere
RECRUITING
Paris
Contact Information
Primary
Estelle GANDJBAKHCH, MD, PhD
estelle.gandjbakhch@aphp.fr
01 42 16 30 55
Backup
Hubert COCHET, MD, PhD
hcochet@wanadoo.fr
05 57 65 65 42
Time Frame
Start Date: 2022-04-01
Estimated Completion Date: 2026-11-01
Participants
Target number of participants: 130
Related Therapeutic Areas
Sponsors
Collaborators: Centre Cardiologique du Nord, University Hospital, Bordeaux
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov